The significance of FSH elevation in young women with disorders of ovulation.

نویسندگان

  • C O'Herlihy
  • R J Pepperell
  • J H Evans
چکیده

High serum follicle stimulating hormone (FSH) values are consistent with ovarian failure. We studied the progress of 67 women aged under 35 years with oligomenorrhoea or secondary amenorrhoea in whom the serum FSH value was greater than 20 U/1. Twenty-four patients remained amenorrhoeic, but 17 ovulated and six conceived, two on two occasions. Coincident mean serum luteinising hormone (LH) concentrations were significantly lower and mean total urinary oestrogen concentrations were significantly higher in patients who subsequently ovulated, but the degree of increase in FSH did not correlate well with later ovarian function. Treatment with oestrogens, clomiphene citrate, human pituitary gonadotrophin, and bromocriptine was of no benefit in inducing an ovarian response while FSH concentrations remained raised. Our results suggest that a considerable proportion of younger women with ovulatory disorders associated with FSH values in the menopausal range will spontaneously resume ovulation and some will conceive.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

A Preliminary Report of A Low-Dose Step-Up Regimen of Recombinant Human FSH for Young Women Undergoing Ovulation Induction with IUI

Background The aim of this study was to evaluate the efficacy and safety of a recombinant human follicle stimulating hormone (r-FSH) low-dose step-up regimen for controlled ovarian hyperstimulation in patients undergoing ovulation induction (OI) with intrauterine insemination (IUI). MaterialsAndMethods The study was conducted in the Department of Obstetrics and Gynecology, Far Eastern Memorial ...

متن کامل

P-67: The Comparison of the IVF Outcome betweenThree Methods of Induction Ovulationin PCOS Patients

Background: Polycystic ovarian syndrome (PCOS) is the most important cause of oligoovulation and anovulation in women of reproductive age and in infertile women . Several approaches have been proposed to induce ovulation in pcos pastients and gonadotropins are the classical and effective therapeutic options . This study was carried out with the Backgrounds of comparing of fertility rate with an...

متن کامل

Serum leptin concentration in young adult women with ovulatory dysfunction.

To investigate the functional role of leptin in human ovulation, we measured serum leptin, LH, FSH and estradiol in 16 young adult women suffering from ovulatory dysfunction with BMI ranging from 17.5 to 24.5 (group A). The control subjects included 12 women with regular ovulation and matched age and BMI (group B). We found that serum leptin concentration in group A subjects was significantly l...

متن کامل

P-55: Study of Day Three FSH and LH Level onNumber and Quality of Oocytes in InfertilityWomen Candidate for ART Cycle

Background: Gonadptropins are main regulator of women menstrual cycles during which ovulation occur. infertile women with high level of FSH are poor responder to ovulation during ART cycles and do not take good result. this Study is done to evaluate the effects of day three FSH and LH level on number and quality of fertilized oocytes in infertile women candidate for ART cycle. Based on this stu...

متن کامل

Bye-bye urinary gonadotrophins? Recombinant FSH: a real progress in ovulation induction and IVF?

Whether recombinant gonadotrophin products do, indeed, represent progress for routine ovulation induction and IVF cycles, in comparison with urinary products, has remained controversial. Here we review published data with regard to respective risks, outcomes and cost for both medication options. Safety considerations favour recombinant products, while overall outcome and cost considerations fav...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • British medical journal

دوره 281 6253  شماره 

صفحات  -

تاریخ انتشار 1980